Sinuphend Nasal Decongestant

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1. Sinuphend Nasal Gel (15ml) ($8.95)

2. Sinuphend Paediatric (15ml) ($8.95)
3. Sinuphend Tablets (30's) ($8.95)

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Sinuphend is a nasal decongestant, made from completely natural extracts, providing desperately needed short and long term relief from sinusitis, hayfever, colds and flu.

After years of research, Sinuphend™ & Sinuphend™ Paediatric's revolutionary approach offers patients a safe natural medication, that is fast and effective for the treatment of nasal congestion and sinusitis, free from rebound side effects and dependence.

Sinuphend™ Tablets offers patients a safe natural medication, that is fast and effective for the treatment of colds and flu, nasal congestion and sinusitis, free from the effects of drowsiness that is associated with many products.

Worldwide, there are millions suffering from chronic sinus problems. Common prescription and over-the-counter drugs that try address this problem slow down the flow of mucus (anti-secretory), kill the bacteria (antibiotics), or shut down the swelling (anti-inflammatory). While each strategy gives some people temporary relief, none of these drug approaches deals with the underlying problem. The real problem is usually a fungal infection.

Sinuphend™ is a blend of natural extracts that offers fast acting relief from chronic sinusitis, nasal congestion, nasal discharge, rhinitis of varied origins, catarrh, coryza, hayfever, post-nasal drip and atrophicans. The active ingredients have anti microbial effects on most bacteria, fungi & yeast's and contains no Benzalkonium chloride.

Every season brings along new pollens, fungi, bacteria and other airborn antigens. Sinuphend is designed to counter the allergic immune response to most of these pollutants and pathogens, and encourage nasal discharge, therefore providing both short and long term relief with no side effects.

Pharmacological Actions: Sinuphend™ acts against bacteria, fungi and moulds which trigger the immune response and the primary cause for nasal congestion and sinusitis. Due to an increase in eosinophiles and the resulting release of MBP into the mucus, bacteria proliferates in the damaged sinus lining. The delivery mechanism is a deficient phosphos-lipid, that performs immediate trans dermal penetration of the active ingredients.

* Fast acting

* Non Addictive

* No side effects

* Non prescriptive

* For adults and children

* No artificial preservatives

* Use as often as necessary.

* Fast sinus relief, sinus pressure, & nasal congestion.

1. What is Sinuphend
A Sinuphend is a nasal gel made only from natural ingredients.

2. Why is Sinuphend a gel and not a spray
A A gel is less messy and adheres to the sides of the nasal passages.

3. Is Sinuphend for everyone
A Yes! – there is Sinuphend for ages 6 onwards, but it is more suited to adults. And there is the Paediatric/Sensitive version for small children, babies and pregnant moms and those with sensitive noses

4. Is Sinuphend only for sinusitis?
A. No! – It can be used for nasal congestion, hayfever, colds and the flu.

5. What does Sinuphend do?
A. The primary action to attack bacteria, fungi and moulds the primary reasons for the immune response to nasal congestion and sinusitis. The secondary function is to reduce inflammation and encourage nasal discharge.

6. How does it do this?
A. Refer to the individual active ingredients on pages 4 & 5 on the pharmacological actions.

7. Why use Sinuphend when I can use a normal nasal spray
A Common nasal sprays work primarily on two levels. By killing bacteria, and drying up the mucous. Sinuphend kills both bacteria and fungi. When this is done the nose dries up on it’s own. For sinusitis the worst thing is a drying agent. In order to clear sinusitis the sinuses need to drain, not to dry up.

8. When I use Sinuphend my nose runs constantly.
A. Sinus infections are caused by blocked sinus passages. The mucous in these passages needs to drain. It can take a few days to many weeks depending on the severity. Only when fully drained will sinusitis clear.

9. Why do I need to kill fungi as well as the bacteria
A. A Mayo clinic study proved that sinusitis is first caused by fungi. A GMP protein is made by the body to attack the fungi. This protein causes and irritation in the nasal mucosa which leads to a bacterial response, causing inflammation and congestion. It’s not enough to kill the bacteria you need to kill the fungi as well.

10. Why do people become dependant on nasal sprays.
A. Most nasal sprays both natural and allopathic (eg. Drixine) use an ingredient called Benzalkonium Chloride as a preservative. This chemical causes rebound congestion, which basically causes the nose to block after and hour or two after application. A cycle of dependency occurs with the constant use of the medication in trying to unblock congested nasal passages.

11. Is Benzalkonium Chloride safe to use
A. No! – Three studies have shown that benzalkonium destroys the cilia and nasal mucosa with long term use, especially seen in sinusitis sufferers. The problem is that you don’t feel the harmful effects, and the damage to the cilia and mucosa can never be repaired. Sinuphend uses a natural preservative.

12. Is Sinuphend safe to use
A. Yes, absolutely – There are no side effects, no risk of addiction and no synthetic preservatives. Everything is 100% Natural and it works fast.

13. Will Sinuphend cure my sinusitis
A. No. – This is because every season brings along new pollens, fungi, bacteria and other airborne antigens. Sinuphend is designed to counter the allergic immune response to most of these pollutants and pathogens, and encourage nasal discharge. So we can cure you for a season only.

14. When I use Sinuphend it stings
A. Normal Sinuphend has a slight sting that can last about 5 seconds. After 3-4 applications it becomes less noticeable. If the stinging sensation is severe and continues for more than a minute, then you should use Sinuphend paediatric/Sensitive for sensitive noses. The two reasons for severe stinging are, either you have very sensitive nasal passages or you have destroyed your nasal mucosa from long term use of nasal sprays.

15. The gel has black spots is the product off?
A. No. These are the herbal extracts / tinctures. If you like give the bottle a good shake.

16. What else can I do to help my sinus problems?
A. Try and determine if you have any food allergies. May people have reactions to certain foods and drink. Common items are breads, peanuts, dairy, coffee etc…

17. Comments from users
a. I have suffered from sinusitis for 12 years, after 1 week of Sinuphend my sinusitis has cleared. I only need a maintenance dose every now and again.
b. I started using Sinuphend and my nose ran for 8 weeks before stopping. My head is clear with no pain for the first time in 8 years.
c. I couldn’t use the normal Sinuphend because of the burn from 20 years of nasal sprays. But the Sinuphend for sensitive noses is perfect and I am slowly getting the relief I have always wanted.
d. Many of my customers have commented on the initial sting, but they all agree that it works far better than anything they have used and continue to buy it.

Sinuphend Nasal Gel

Pharmacological Actions: The primary action of Sinuphend is to attack bacteria, fungi and moulds the primary reasons for the immune response to nasal congestion and sinusitis. The secondary function is to reduce inflammation and encourage nasal discharge.

What do the active ingredients do?
Colloidal Silver (5ppm) is absolutely safe for humans and all multi-celled living matter Colloidal silver acts as a catalyst, disabling the enzyme that all one-celled bacteria, fungi, and viruses use for their oxygen metabolism. This proves lethal to over 650 different diseases, fungi, parasites, moulds, and bacterial and viral conditions but has proven completely non-toxic to the body, animals, and plants.
Phytotherapy Research, May 2000, Journal Applied Microbiology, Volume 88, 2000 (J Periodontal Res. 2001 Apr;36(2):108-13), J Biomed Mater Res. 2000 Dec 15;52(4):662-8, Biol Met 1990;3(3-4):151-4, J Oral Maxillofac Surg. 1987 Sep;45(9):779-84

Urtica Dioica reduces the inflammatory disorder of the nasal mucosa.
Altern Med Rev. 2000 Oct;5(5):448-54

Olea europa has antiviral, antifungal, and antibacterial properties. The active compounds elenolic acid, calcium elenolate oleuropein , were found that these chemicals ward off virus, bacterium or protozoan influenza, parasitic protozoan, fungus, and yeast infections

Mineral salt - A natural saline solution comprising natural minerals, matching the salinity of the body and aids in nasal discharge.

Emu oil - Acts as a natural anti-inflammatory and trans-dermal vehicle for transporting active ingredients through the skin.

Citrus Grandis - is a natural antimicrobial ingredient being used to kill Strep, Staph, Salmonella, E. Coli, Influenza, parasites, that is widely recognized for nose and throat irritations. It is effective against more than 800 bacterial and viral organisms, 100 strains of fungus, and a large number of single-cell and multi-celled parasites. To date there is no evidence that any type of pathogenic micro-organism has ever built up a resistance to citrus grandis. Due to the mode of its activity, it is believed that this resistance is impossible as CG disrupts the organisms cytoplasmic membrane

Pulsatilla – has antiviral activity and is effective in upper respiratory tract infections
Forsch Komplementarmed Klass Naturheilkd. 2001 Aug;8(4):207-12.
Complement Ther Med. 2004 Jun;12(2-3):112-7.

Echinacea - boosts the body’s immunity against viral, fungal, and bacterial infections, and quickly alleviates the symptoms of the common cold.
References:
Echinacea: Nature's Immune Enhancer by Stephen Foster, Naturopathic Handbook of Herbal Formulas by Herbal Research Publications, Inc.
Herbal Tonic Therapies by Daniel B. Mowrey, Ph.D. Earl Mindell's Herb Bible by Earl Mindell, R.Ph., Ph.D.
Phytomedicine. 1999 Mar;6(1):1-6.
Schulten 2001).
(JAMA) (290, 21:2824-30, 2003)

Hydrastis – therapeutic properties are attributable to its berberine and hydrastine content, by alleviating inflammation of the mucous membranes.
Planta Med. 2001 Aug;67(6):561-4.

SIDE EFFECTS FROM COMMON NASAL DECONGSTANTS INCLUDE:
REBOUND CONGESTION and DEPENDENCY (BENZALKONIUM CHLORIDE)

Dependency and Rebound. The major hazard with nasal-delivery decongestants, particularly long-acting forms is a cycle of dependency and rebound effects. The 12-hour brands pose a particular risk for this effect. This effect works in the following way:
• With prolonged use (more than three to five days), nasal decongestants lose effectiveness and even cause swelling in the nasal passages.
• The patient then increases the frequency of their dose. The congestion worsens and the patient responds with even more frequent doses, in some cases to as often as every hour.
• Individuals then become dependent on them.
About 1985 it was noted that the number and severity of cases of rhinitis medicamentosum was increasing in proportion to the use of benzalkonium, an antibacterial preservative found in most on the shelf prepared saline nasal spray products. Rhinitis medicamentosum means that the nose gets stuffy and congested after use of nose drops such as oxymetazoline. The more the nose drops are used, the more rebound when the drug wears off, so that the drops become almost addicting and hard to stop. The nose is stuffier after use.
Then it was discovered that you could get rhinitis medicamentosum just form the Benzalkonium alone, as well as saline with Benzalkonium. So, it wasn't the nasal medication that was responsible, but the Benzalkonium.
When you are allergic or with an infection, the chemicals can be more irritating than when you are "normal".
Recent articles on the negative effects of Benzalkonium include:
Berg: Mucosa exposed to benzalkonium chloride showed squamus cell metaplasia ( the normal cells changed to undesirable cells). Benzalkonium chloride appears to be potentially toxic to the mucosa.
Steinsvag: benzalkonium chloride has toxic effects on human respiratory mucosa and human neutrophils. It destroyed mucosa and inhibited human neutrophil action Benzalkonium chloride induces mucosal swelling, which explains why the presence of this preservative in a decongestant spray aggravates rhinitis medicamentosa.
Hoffman An irreversible cessation of ciliary movement was observed in ciliary cells exposed to nasal sprays containing Benzalkonium chloride As benzalkonium chloride can cause complete standstill of ciliary beat frequency in vitro in human nasal mucosa, we recommend that this preservative should not be used anymore in topical nasal medications.

Sinuphend Tablets

Sinuphend Tablets offers patients a safe natural medication, that is fast and effective for the treatment of colds and flu, nasal congestion and sinusitis, free from the effects of drowsiness that is associated with many other products.

Sinuphend tablets is a well researched formula backed by clinical trials and studies proving there effectiveness against symptoms of Flu, Colds and Sinusitis.

Sinuphend Tablets contain:
Quercetin is an excellent antioxidant that enhances the effectiveness of vitamin C, and helps strengthen the walls of the intricate blood vessels in the nasal passages. It is believed to stabilize mast cells, which contain the histamine during an allergic attack.

Quercetin reduces the inflamma¬tory response by inhibiting release of pro-inflammatory leukotrienes, which are one of the most potent pro-inflammatory substances produced by our bodies. Quercetin also protects white blood cells which, when damaged, release pro-inflammatory histamine and may also have anti-viral activity. Bioflavonoids may help decrease swelling by reducing capillary fragility and permeability. In human studies, the inflammatory response was decreased when bioflavonoids were given in combination with vitamin C, an outcome con¬firmed in double-blinded research.

Curcumin possess many health-protective benefits by providing broad-spectrum effects throughout the body as a potent antioxidant, plus it suppresses the enzyme COX-2 which is important for good health.

Echinacea supports the immune system by promoting the production and activity of white blood cells. It also increases production of interferon, an important part of the body’s natural defences.

Golden Seal contains special health-promoting properties, and has been used for the sinuses, eyes, mouth and throat

Nettle contains unique, natural properties that help maintain healthy sinuses.

Vitamin C supports the production of glutathione, a potent antioxidant, thereby promoting sinus and respiratory health. It has mild antihistamine activity and as a possible consequence, some studies have reported that vitamin C is useful in reducing painful, swollen nasal passages.

N-Acetyl cystein is an amino acid that is a major glutathione antioxidant precursor protecting against free radical damage, thereby promoting healthy sinus and respiratory function.

Bromelaine enzyme has been credited with breaking down fibrin, a blood-clotting protein that can impede good circulation and prevent tissues from draining properly. It is approved by the German commission for sinus and nasal swelling after ENT Surgery, and has anti-histamine properties.
Bromelaine helps inhibit the formation of prostaglandins that trigger the inflammatory response. It also makes mucus less thick, allowing mucus to drain more easily. Fibrin is a protein that concentrates in areas of inflammation, causing painful swelling. Bromelaine decreases fibrin deposits, preventing damaging build-up in the sinuses and elsewhere.
Human trials have shown that by removing fibrin from areas of inflammation, bromelain lessens swelling. Inflamed sinuses respond well to bromelain. Double-blinded trials show that the inflammatory response is better reduced by bromelain than by placebo. In all cases, a majority of people responded well.

Zinc helps maintain healthy cell membranes, protect cells against free radicals, and is essential for the transport of various nutrients involved in maintenance of tissue health.

Grape Fruit Seed extract has proven to be a safe, powerful and natural herb to promote healthy sinus function

Medical References:
QJM: Int’l J. of Medicine, Jan. 2003 / Periodontal Res. 2001 Apr;36(2):108-13), / J Biomed Mater Res. 2000 Dec 15;52(4):662-8 / FEBS Lett 1995;351:215-218. / Eur J Pharmacol 1988;150:295-301. / Immunpharmacol 1997;35:229–35. / J Natl Cancer Inst 1989;81:669–75. / Clin Biochem 1994;27:245–8. / Biochem Biophys Res Commun 1995;206:533-540. / Prac¬titioner 1969;203:206. Exper Med Surg 1962;20:228-48. J Am Coll Nutr 1992;11:172-6. Med Times 1960;88:313-6. Arch Allergy Applied Immunol 1985;77:155-7. / Med Hypoth 1980;6:99-104. / EENT Monthly 1966;45:96-8. / EENT Monthly 1967;46:361-5. / Headache 1967;7:13-7. / EENT Monthly 1967;46:1281-8. / Prog Clin Biol Res 1986;213:231-42. / Med Times 1962;529-32. / J Am Diet Assoc 1992;92(8):988-9. / Am J Dig Dis 1945;12:281. / J Allergy Clin Immunol 1973;51:218. / Science 1942;96;497. / J Allergy Clin Immunol 1982;69:484-8. / NZ Med J 1986;99:163 [abstr].